Collaborative Study : In this page, the thematic area in which the department is looking for collaboration/MoU for the expertise is sought.

Please send an E-mail to Closing Date: 30/05/2023

Title Expression of Interest for Collaborative Study: Assessment of geometrical dose distribution, persistence of induced DNA damage and cancer risk estimation in pediatric subjects after computed tomography imaging.
Theme Medical uses of ionizing radiation are for eternity based on the risk vs benefit. Diagnostic procedures are the largest man-made source of radiation exposure to the general public, contributing about 14% of the total annual exposure (2.8 mSv) worldwide; out of which the CT imaging alone contributes about 47%. In specific for each CT scan the range of absorbed dose was 5-50 mGy to each organ imaged to the subject with an average of 4.5 mSv. Initially, it was thought that the cancer risk associated with CT scanning was speculation; risks of medical imaging are too low to be detectable and may be nonexistent. While the diagnostic potential of CT imaging is immense and accepted universally, its usage raised concern owing to increased risk of cancer of brain and leukemia in subjects underwent CT imaging; especially, the risk is higher in pediatric age groups rather than adults. In line with global literature (pediatric age groups receive more dose and high risk for cancer of brain and leukemia), it was decided to carry out an extensive and systematic study on the pediatric age group with higher sensitive biomarkers and relate the absorbed dose to risk estimation for cancer at national level. Being the first at the national level for the regional population, dose reduction strategies can be planned for the better exploiting the diagnostic potential of CT without any hesitation or public fear.
Scope of the Study The main objective of the study is to carry out a systematic study on the pediatric age group who underwent CT imaging with higher sensitive biomarkers and relate the absorbed dose to risk estimation for cancer at national level
  • Assessment of the doses received at different anatomical locations on the entire body in pediatric age group during CT imaging
  • To investigate basal and induced DNA damage (γ-H2AX), telomerase activity and gene expression (regulating check point activation, DNA repair and proliferation) in blood lymphocytes of study subjects before and after the CT imaging
  • To investigate the persistence/kinetics of low dose radiation induced DNA damages (Translocations by FISH) in study subjects (up to 180 day of post CT imaging)
  • To predict risk for the development of cancer from the registered dose with Monte-Carlo stimulation

Expected Expertise

Academic / Research Institutes with expertise in field radiation biology to assess DNA damage, gene expression studies, Translocation analysis from human blood samples (evidence in the form of publication / previous experience in conduct of similar study with either national/international support should be submitted). Also the institute should have ethical committee and access to pediatric patients undergoing CT imaging. Dedicated Radiology and Imaging Sciences department with national level accreditation to collect reliable physical dosimetry data is desirable

Contact :

Dr. O. Annalakshmi
Head, RDS, EAD
Safety, Quality and Resource Management Group (SQRMG),
Indira Gandhi Centre for Atomic Research
Kalpakkam - 603102 .
PH: 044+27480500 -23421